What is SPELL?
SPELL predicts potential split sites in proteins so that two halves of a split protein can reassemble into a full protein upon ligand or light stimulation.
The server ranks candidate split sites according to prediction reliability and keeps the original reference materials available alongside the prediction workflow.
How to cite SPELL
Dagliyan O, Krokhotin A, Ozkan-Dagliyan I, Deiters A, Der CJ, Hahn KM, Dokholyan NV. Computational design of chemogenetic and optogenetic split proteins. Nature communications. 2018 Oct 2;9(1):4042.
If you use SPELL in a publication, please cite the original SPELL paper and mention that the server predicts potential split sites in proteins.